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Inhibition of adenylyl cyclase activity via stimulation of A1 receptors. Adenylyl cyclase was stimulated with forskolin (F) and concentration-dependent inhibition by fludarabine, clofarabine and cladribine is shown. The maximal inhibition is comparable to the full A1 receptor agonist CCPA. Data represent percent of forskolin-stimulated cyclase activity over basal (n = 3, error bars show SEM).
