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Effect of clofarabine, cladribine and fludarabine on adenylyl cyclase activity. Values are IC50 (EC50 for A2B) given in nM with 95% confidence intervals in parentheses (n=3).
| A1 | A2A | A2B | |
|---|---|---|---|
| clofarabine | 3,130 (1,890-5,190) | 9,800 (8,120-11,800) | > 100,000 |
| cladribine | > 10,000 | 16,100 (10,500-24,700) | > 100,000 |
| fludarabine | > 10,000 | n.d. | > 100,000 |
n.d., not determined
