Table 3.
Functional identification of proteins differing from the control taken from the 103 h sample of the Escherichia coli culture continuously grown in the presence of erythromycin (10 μg mL−1)
No. | Protein name | Gene | Function | 43 h | 68 h | 103 h |
---|---|---|---|---|---|---|
5201 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | dapD | Amino acid metabolism | Up | ||
2101 | Histidine-binding periplasmic protein | hisJ | Amino acid transport | Up | ||
0005 | Glucose-specific phosphotransferase enzyme IIA component | ptsG | Sugar transport | Up | ||
5206 | UTP–glucose-1-phosphate uridylyltransferase | galU | Carbohydrate metabolism | Up | ||
0002 | Acyl carrier protein | acpP | Lipid metabolism | Up | Up | |
1201 | Malonyl CoA-acyl carrier protein transacylase | fabD | Lipid metabolism | Up | ||
5003 | ATP-dependent Clp protease proteolytic subunit | clpA | Proteolysis | Up | ||
1104 | Agmatinase | speB | Polyamine synthesis | Up | ||
0204 | Spermidine/putrescine-binding periplasmic protein | potD | Polyamine transport | Down | Up | |
5106 | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG | ydfG | E-Oxidoreductases | Up | ||
0101 | Fe/S biogenesis protein nfuA | nfuA | Stress response | Up | ||
1105 | MltA-interacting protein | mipA | Outer membrane proteins | Up | ||
0301 | Outer membrane protein C | ompC | Outer membrane proteins | Up | ||
0201 | Uncharacterized protein yceD | yceD | Uncharacterized protein | Up | ||
7603 | ATP synthase subunit alpha | atpA | ATP synthesis | Down |
The proteins' up- or downregulation is marked for each sampling time point.