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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: FEBS J. 2013 Jun 7;280(14):10.1111/febs.12328. doi: 10.1111/febs.12328

Figure 4. Effect of mutation of surface-exposed cationic residues.

Figure 4

A: The comparison of surface-exposed cationic residues of SDF-1 (left) and hBD-3 (right). Panels B through F show the inhibition of SDF-1α-triggered Ca2+ mobilization by hBD-3 mutants. B: mutant K8A; C: mutant K32S; D: mutant R36I; E: mutant 8–32 (K8A/K32S); F: mutant 8-32-36 (K8A/K32S/R36I); G: inhibition of high-affinity SDF-1α binding by 8-32-36.