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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: FEBS J. 2013 Jun 7;280(14):10.1111/febs.12328. doi: 10.1111/febs.12328

Figure 6. Effect of the C-terminal mutations on activity of hBD3.

Figure 6

Panels A through F illustrate inhibition of the SDF-1α-induced Ca2+ mobilization by several C-terminal hBD-3 mutants. A: mutant SSKK (R42S/R43S-hBD3); B: mutant RRGG (K44G/K45G-hBD3); C: mutant AAGG (R42A/R43A/K44G/K45G-hBD3); D: mutant RRKKRRRK (insert RRRK at C-terminus of hBD3); E: mutant CA (R42E/R43E/K44S/K45S-hBD3); F: mutant CA-NC (N4R/T5R/R42E/R43E/K44S/K45S-hBD3); G: inhibition of high-affinity SDF-1α binding by several hBD-3 mutants.