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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: FEBS J. 2013 Jun 7;280(14):10.1111/febs.12328. doi: 10.1111/febs.12328

Figure 8. Determining minimal hBD-3 structure for blocking CXCR4.

Figure 8

Inhibition of the SDF-1α-induced Ca2+-mobilization by three hBD-3 mutants, 6–45 (delete G1 through T5 of hBD3), 11–45 (delete G1 through Y10 of hBD3), and 6–41 (delete G1 through T5 and R42 through K45 of hBD3), with various truncations of the N-terminal region. Bar graph shows inhibition of high-affinity SDF-1α-binding by these mutants.