Table 2.

Significant SNPs identified from the Discovery and Combined replication datasets

	SNP rs#	chr	Location*	# of transmission	Minor allele	MAF**	Over transmitted allele	P-value	# of transmission	Minor allele	MAF	Over transmitted allele	P-value
EGFR	11770506	7	55090379	238	C	0.335	T	0.0014	541	C	0.334	T	0.0066
EGFR	763317	7	55095197	230	A	0.472	A	0.0349	547	A	0.306	A	0.016
EGFR	6956366	7	55101501	231	C	0.333	G	0.0110	579	C	0.329	G	0.0044
EGFR	12668421	7	55109177	235	A	0.197	T	0.0003	600	A	0.209	T	0.0261
EGFR	723527	7	55134872	237	G	0.406	A	0.0120	600	G	0.427	A	0.0507
EGFR	11487218	7	55141540	236	C	0.373	C	0.027	583	C	0.353	C	0.5382
EGFR	7780270	7	55151886	235	T	0.475	G	0.0247	592	T	0.489	G	0.0882
ERBB4	1836721 ***	2	212252194	238	A	0.101	T	0.0467
ERBB4	12052398	2	212355840	230	G	0.305	A	0.0280	577	G	0.293	A	0.0672
ERBB4	13424871	2	212531352	230	A	0.243	A	0.0091	574	A	0.249	A	0.1802
ERBB4	11892696	2	212710146	236	C	0.206	T	0.0003	598	C	0.220	T	0.0364
ERBB4	16847082	2	212718670	235	C	0.197	T	0.0003	600	C	0.209	T	0.0261
ERBB4	1978873	2	212765835	238	A	0.082	G	0.0186	606	A	0.080	G	0.1191
ERBB4	16847416 ***	2	212847605	238	G	0.026	A	0.0225

^*Location is based on human genome assembly GRCh37/hg19

^**MAF – minor allele frequency

^***Unable to generate ABI TaqMan probes for AT1836721 and AG16847416