Figure 1.

Structures of LptA and LptC. (A) The LptA dimer observed in the 2R19 crystal structure¹² with sites Q148 and K149 highlighted. The K149 side chain was not resolved and is missing from the structure. (B) The N-terminal amino acids 35–47 and the C-terminal amino acids 148–165 of LptA are aligned based on the crystallographic oligomer. The gap occurs because the C-terminal loop in the fold of the β-strand is longer than in the N-terminus edge strand. Amino acids K149 and Q148 are underlined. (C) Docked model of the LptC (green;3MY2)-LptA (blue; 2R19) interaction based on the LptA dimer structure. Reporter sites Y182 LptC and I36 LptA used for the affinity studies are labeled.