TABLE 1.

Transcript levels of young (10 generations) and old (45 generations) aerobic, maltose-limited chemostat cultures of S. cerevisiae CEN.PK113-7D

Enzyme	Locus		Transcript levela		Fold change (old vs young culture)	P valueb
	Systematic name	Standard name	Young culture	Old culture
Maltose permease	YGR289C	MAL11	20,015 ± 2,127	24,930 ± 248	1.2	0.19
	YBR298C	MAL31	12,721 ± 813	15,587 ± 1,056	1.4	0.04
	YDL247W		258 ± 152	430 ± 455	1.7	0.69
	YJR160C		229 ± 85	363 ± 187	1.6	0.49
	Total		33,223 ± 2284	41,310 ± 1,191	1.2	0.04
Maltase	YBR299W	MAL32	17,626 ± 310	20,011 ± 404	1.1	0.03
	YJL221C	FSP2	3,018 ± 545	8,232 ± 2,208	2.7	0.17
	YGR287C		1,698 ± 384	5,059 ± 863	3.0	0.08
	YJL216C		813 ± 207	1,084 ± 37	1.3	0.31
	Total		23,155 ± 764	34,386 ± 2,405	1.5	0.00
Maltose activator	YGR288W	MAL13	282 ± 2	337 ± 76	1.2	0.49
		MAL23	Ac	A
	YBR297W	MAL33	865 ± 287	834 ± 38	−1.0	0.90
	YPR196W		2,863 ± 106	3,670 ± 378	1.3	0.18
	YFL052W		A	A
	Total		3,728 ± 306	4,504 ± 380	1.2	0.15

^aAverage transcript levels and their mean deviations were calculated from two independent chemostat cultures.

^bDetermined by Student's t test (a P value of ≤0.05 is considered significant).

^cA, transcript defined as absent by the algorithm implemented in version 4.01 of the Affymetrix Microarray Suite software.