Table 1.

Parameter correspondence between the allosteric two-state model (Equation 5) and the operational model of allosterism including constitutive receptor activity (Equation 8)

Pharmacological property	Allosteric two-state model	Operational model of allosterism
Constitutive receptor activity (basal response)	L	χ
Agonist concentration	[A]	[A]
Allosteric modulator concentration	[B]	[B]
Agonist dissociation constant	K	K
Allosteric modulator dissociation constant	M	M
Intrinsic efficacy of A	α	εA
Intrinsic efficacy of B	β	εB
Binding cooperativity between A and B	γ	α
Activation cooperativity between A and B	δ	δ

Note the α used has two different meanings: intrinsic efficacy of A in the allosteric two-state model and binding co-operativity between A and B in the operational model of allosterism. This was done as a compromise to preserve consistency with conventional model parameters used in reference publications (Hall, 2000; Leach et al., 2007).