Table 1.

Impact of Cl-indole (10 μM) upon the affinity (pK_i) of 5-HT and tropisetron (ICS 205–930; (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1methyl-indole-3-carboxylate) and Hill coefficient for the h5-HT₃A receptor radiolabelled with [³H]granisetron

	pKi	Hill coefficient
5-HT	6.31 ± 0.03	1.59 ± 0.21
5-HT + Cl-indole	6.57 ± 0.03*	1.44 ± 0.13
Tropisetron	8.50 ± 0.10	1.00 ± 0.03
Tropisetron + Cl-indole	8.39 ± 0.06	0.99 ± 0.04

Data represents mean ± SEM from four independent experiments. Effect of Cl-indole

^*P < 0.05.