Table 4.

Integrated (0–30 min) changes in cardiovascular variables following administration of retigabine (3 mg·kg⁻¹)

Pretreatment	Saline (n = 5)	Propranolol (n = 6)	CGP 20712A (n = 6)	ICI 118551 (n = 6)
HR (AOC, beats)	+340 ± 219	+0.2 ± 0.2*	+0.5 ± 0.3*	+57 ± 38
HR (AUC, beats)	−409 ± 211	−392 ± 56	−461 ± 76	−1055 ± 800
MAP (mmHg min)	−205 ± 87	−508 ± 39*	−391 ± 97	−405 ± 179
RVC (% min)	+220 ± 140	+387 ± 98	+266 ± 103	+344 ± 166
MVC (% min)	+77 ± 39	+551 ± 117*	+288 ± 155	+76 ± 25
HVC (% min)	+726 ± 85	+378 ± 72*	+877 ± 142	+350 ± 146*

Values are mean ± SEM.

^*P < 0.05 versus saline group (Kruskal–Wallis). For other abbreviations see Table 1 (Experiment 2).

AOC, area over the curve; AUC, area under the curve.