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. 2013 Jun 21;169(6):1335–1351. doi: 10.1111/bph.12225

Figure 5.

Figure 5

Effect of ETBR-mediated activation. Microvessels of virgin and pregnant rats were pretreated with the ETAR antagonist BQ-123 (10−6 M) to block ETAR-mediated vasoconstriction. Microvessels were then preconstricted with PHE (6 × 10−6 M), then stimulated with increasing concentrations of ET-1 (10−11–10−7 M), and the % relaxation of PHE contraction (A) and underlying [Ca2+]i (B) was recorded. Concentration–relaxation curves (C, E) and underlying [Ca2+]i (D, F) in response to the ETBR agonist S6c (10−11–10−7 M) (C, D) and IRL-1620 (10−11–10−7 M) (E, F) were compared in microvessels of virgin and pregnant rats. Line graphs represent means ± SEM of vasodilation and [Ca2+]i, n = 8–12 different rats per group. *P < 0.05, pregnant versus virgin.