Table 1.
Time-to-peak and time-to-steady-state vasoconstriction and [Ca2+]i in response to KCl (51 mM), PHE (10−5 M) and ET-1 (10−7 M) in mesenteric microvessels of virgin and pregnant rats
| Virgin | Pregnant | |||||
|---|---|---|---|---|---|---|
| KCl | PHE | ET-1 | KCl | PHE | ET-1 | |
| Time-to-maximum constriction (s) | 18.7 ± 2.4 | 16.6 ± 2.5 | 69.4 ± 10.9# | 22.3 ± 1.8 | 19.8 ± 2.8 | 39.7 ± 6.7*# |
| Time-to-peak [Ca2+]i (s) | 11.2 ± 0.7 | 10.9 ± 1.4 | 24.3 ± 3.6# | 11.3 ± 1.0 | 12.9 ± 1.7 | 18.9 ± 2.7 |
| Time-to-steady-state constriction (s) | 33.6 ± 5.4 | 31.9 ± 4.6 | 88.7 ± 14.8# | 40.4 ± 4.2 | 37.3 ± 2.7 | 76.3 ± 10.7# |
| Time-to-steady-state [Ca2+]i (s) | 36.7 ± 2.9 | 42.6 ± 8.6 | 95.3 ± 9.4# | 34.4 ± 5.4 | 36.7 ± 3.1 | 102.0 ± 14.3# |
s, sec.
n = 8–12 different rats per group.
*
P < 0.05 pregnant versus virgin.
#
P < 0.05, measurements during stimulation with ET-1 are significantly different from corresponding measurements during stimulation with KCl or PHE.