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. 2013 Jun 21;169(6):1352–1371. doi: 10.1111/bph.12226

Figure 3.

Figure 3

Quercetin and allopurinol suppress hepatic oxidative stress and TXNIP in STZ-induced diabetic rats. Biochemical analyses showing hepatic levels of XO (A) and XDH (B), the ratio of XO:XDH (C), hepatic levels of O2•− (D) and H2O2 (E) at week 7 after STZ injection in different groups of rats as indicated. The data are expressed as the means ± SEM (n = 8). ++P < 0.01, +++P < 0.001 versus normal control; *P < 0.05, **P < 0.01, ***P < 0.001 versus diabetic control. Representative RT-PCR (F) or Western blot (G) results and graphic presentation showed hepatic TXNIP mRNA and protein levels at week 7 after STZ injection in different groups of rats respectively. The relative mRNA and protein levels were determined after normalization with GAPDH. The data are expressed as the means ± SEM (n = 4). +++P < 0.001 versus normal control; **P < 0.01, ***P < 0.001 versus diabetic control.