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. 2013 Jun 21;169(6):1352–1371. doi: 10.1111/bph.12226

Figure 5.

Figure 5

Quercetin and allopurinol reduce IL-1β and IL-18 levels, and inhibit hepatic NLRP3 inflammasome activation in STZ-induced diabetic rats. Biochemical analyses showed serum and liver levels of IL-1β (A, C) and IL-18 (B, D) at week 7 after STZ injection in different groups of rats as indicated (n = 8). Representative RT-PCR results (E) and graphic presentation shows hepatic mRNA levels of NRLP3 (F), ASC (G) and caspase-1 (H) at week 7 after STZ injection in different groups of rats as indicated. Representative Western blot results (I) and graphic presentation shows hepatic protein levels of NLRP3 (J), ASC (K) and caspase-1 (L) in different groups of rats as indicated. Relative mRNA and protein levels of NLRP3, ASC and caspase-1 were determined after normalization with GAPDH (n = 4). The data are expressed as the means ± SEM. +++P < 0.001 versus normal control; *P < 0.05, **P < 0.01, ***P < 0.001 versus diabetic control.