Fig. 8.

Productive, phosphoryl transfer competent (left) and non-productive, phopshoryl transfer incompetent (right) complexes of IIA^Man and IIB^Man. Both productive and non-productive complexes are significantly populated in the absence of phosphorylation or mutation of His10 of IIA^Man to Glu to mimic the phosphorylated state. The latter mutation shifts the equilibrium almost entirely to the productive complex. The two subunits of IIA^Man are shown in blue and red, respectively, and IIB^Man is in green. Only a single IIB^Man molecule is shown for clarity. Adapted from [20].