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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Cancer Res. 2013 Oct 4;73(20):10.1158/0008-5472.CAN-13-1558-T. doi: 10.1158/0008-5472.CAN-13-1558-T

Figure 2. IL6 is necessary for PanIN progression and maintenance.

Figure 2

(A) Experimental design, n=4~7. (B) H&E and p-ERK1/2 staining (insets) of iKras* and iKras*;IL6−/− mice pancreata 3 weeks, 5 weeks~8 weeks and 17 weeks following pancreatitis. Scale bar 50μm. (C) Gomori Trichrome staining and Periodic Acid Schiff staining (insets) of iKras* and iKras*;IL6−/− mice pancreata. Scale bar 50μm. (D) Transmission electron microscope image of iKras* and iKras*;IL6−/− mice pancreata 5 weeks following pancreatitis. Scale bar 10μm. (E) Pathological analysis. Data represent mean ± SEM, n=3~5. The statistical difference between iKras* and iKras*;IL6−/− mice at the same time point per lesion type was determined by two-sided Student’s t-test. *p<0.05, **p<0.01, ****p<0.0001, #not significant.