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The effects of 50 ng/mL TNF-α on the LCC and ICa-L. (A) Specimen record showing the time course of effect on peak ICa-L. (B) Specimen current traces from the periods highlighted in A. (C) Mean peak ICa-L. (D) Mean Ca influx on the ICa-L. (E) Mean LCC inactivation time (90–10% of peak ICa-L). In all panels, the periods compared are control, initial TNF-α application (within 20 sec), and sustained TNF-α application (∼3 min).
