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IPA constructed network of key molecules selected from those with the greatest fold changes (Esm1, CX3CL1, CD74, HLA-DR, TGFβ3, ILβ1, GADD45α, SLC7A1), members of highest scored Canonical pathways (eNOS, SLC7A1, AGT, AT1R, TGFβ3), and the NAD(P)H oxidase component, CYBA. Altered regulation of several of these molecules was confirmed by RT-PCR (Table 8). IPA generated connections between the molecules and overlaid specific functions.
