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. 2013 Jun 26;1(2):e0005. doi: 10.1002/phy2.5

Table 3.

IPA highest ranked canonical pathways

Ingenuity canonical pathways Analysis name Ratio P-value Molecules
(A) Significantly altered in WKY but not SHR
 Nitric Oxide Signaling in the Cardiovascular System WKY 0.050 0.000 PRKAR2B,PLN,GUCY1A3,SLC7A1,ATP2A3
 Nitric Oxide Signaling in the Cardiovascular System SHR 0.020 0.091 ITPR3,ATP2A2
 IL-1 Signaling WKY 0.047 0.001 GNB1,FOS,JUN,PRKAR2B,ADCY6
 IL-1 Signaling SHR 0.019 0.117 GNG11,GNB2
 TGF-β Signaling WKY 0.045 0.003 FOS,JUN,TGFB3,SERPINE1
 TGF-β Signaling SHR NA NA
 Renin–Angiotensin Signaling WKY 0.040 0.001 FOS,JUN,PRKAR2B,ADCY6,AGT
 Renin–Angiotensin Signaling SHR 0.016 0.154 ITPR3,AGTR1
(B) Significantly altered in SHR but not WKY
 Mitochondrial Dysfunction SHR 0.040 0.000 NDUFS7,XDH,COX8A,COX7A2L,APP,NDUFB2,NDUFB10
 Mitochondrial Dysfunction WKY 0.017 0.079 NDUFS5,COX8A,TXNRD2
 Insulin Receptor Signaling SHR 0.036 0.001 RPS6KB1,BAD,EIF2B3,GSK3B,PPP1CA
 Insulin Receptor Signaling WKY 0.014 0.254 PRKAR2B,EIF4EBP1

ADCY6, adenylate cyclase 6; AGT, angiotensinogen; AGTR1, angiotensin II receptor, type 1; APP, amyloid beta (A4) precursor protein; ATP2A2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATP2A3, ATPase, Ca++ transporting, ubiquitous; BAD, BCL2-associated agonist of cell death; COX7A2L, cytochrome c oxidase subunit VIIa polypeptide 2 like; COX8A, cytochrome c oxidase subunit VIIIa; EIF2B3, eukaryotic translation initiation factor 2B, subunit 3; EIF4EBP1, eukaryotic translation initiation factor 4E-binding protein 1; FOS, FBJ osteosarcoma oncogene; GNB1, guanine nucleotide-binding protein (G protein), beta polypeptide 1; GNB2, guanine nucleotide-binding protein (G protein), beta polypeptide 2; GNG11, guanine nucleotide-binding protein (G protein), gamma 11; GSK3B, glycogen synthase kinase 3 beta; GUCY1A3, guanylate cyclase 1, soluble, alpha 3; ITPR3, inositol 1,4,5-trisphosphate receptor, type 3; JUN, jun proto-oncogene; NDUFB10, NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10; NDUFB2, NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2; NDUFS5, NADH dehydrogenase (ubiquinone) Fe-S protein 5; NDUFS7, NADH dehydrogenase (ubiquinone) Fe-S protein 7; PLN, phospholamban; PPP1CA, protein phosphatase 1, catalytic subunit, alpha isozyme; PRKAR2B, protein kinase, cAMP dependent regulatory, type II beta; PRKAR2B, protein kinase, cAMP dependent regulatory, type II beta; PRKAR2B, protein kinase, cAMP dependent regulatory, type II beta; RPS6KB1, ribosomal protein S6 kinase, polypeptide 1; SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SLC7A1, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; TGFB3, transforming growth factor, beta 3; TXNRD2, thioredoxin reductase 2; XDH, xanthine dehydrogenase. IPA, Ingenuity® pathway analysis; WKY, Wistar Kyoto; SHR, spontaneously hypertensive rat; IL, interleukin; TGF, transforming growth factor.