Table 4.

Molecules with greatest fold changes in collateral expression in WKY with comparison to SHR

WKY fold change	WKY P-value	SHR fold change	SHR P-value	Symbol	Entrez gene name
3.97	0.002	1.72	0.413	ESM1	Endothelial cell-specific molecule 1
2.84	0.012	−1.00	0.989	COL12A1	Collagen, type XII, alpha 1
2.65	0.010	1.22	0.505	SLC7A1	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
2.48	0.019	1.41	0.422	IL1B	Interleukin 1, beta
2.42	0.035	1.70	0.174	DIO3	Deiodinase, iodothyronine, type III
2.37	0.010	−0.98	0.925	ACTA1	Actin, alpha 1, skeletal muscle
2.28	0.031	−1.01	0.984	CRYAB	Crystallin, alpha B
2.25	0.002	−1.05	0.899	IDI1	Isopentenyl-diphosphate delta-isomerase 1
2.25	0.007	−1.79	0.123	TGFB3	Transforming growth factor, beta 3
2.19	0.041	1.31	0.419	CYP51A1	Cytochrome P450, family 51, subfamily A, polypeptide 1
−6.45	0.039	−1.27	0.595	AGT	Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
−4.08	0.016	−2.61	0.053	SULT1A1	Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
−3.44	0.048	−1.32	0.243	TNXA	Tenascin XA
−2.93	0.049	−2.08	0.679	JUN	Jun proto-oncogene
−2.86	0.000	−1.97	0.128	GSTT2	Glutathione S-transferase theta 2
−2.84	0.010	−2.21	0.034	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide
−2.74	0.044	−1.65	0.113	EPHX1	Epoxide hydrolase 1, microsomal (xenobiotic)
−2.68	0.001	−2.32	0.623	FMOD	Fibromodulin
−2.49	0.029	−1.86	0.182	EEF2K	Eukaryotic elongation factor-2 kinase
−2.48	0.025	−0.68	0.831	CX3CL1	Chemokine (C-X3-C motif) ligand 1

IPA, Ingenuity® pathway analysis; WKY, Wistar Kyoto; SHR, spontaneously hypertensive rat.