Table 5.

Molecules with greatest fold changes in collateral expression in SHR with comparison to WKY

SHR fold change	SHRP-value	WKY fold change	WKY P-value	Symbol	Entrez gene name
3.40	0.049	1.38	0.822	CYP4A14	Cytochrome P450, family 4, subfamily a, polypeptide 14
1.91	0.011	1.10	0.650	AKAP11	A kinase (PRKA) anchor protein 11
1.91	0.034	1.16	0.773	GADD45A	Growth arrest and DNA-damage-inducible, alpha
1.89	0.047	1.72	0.172	EIF2B3	Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58 kDa
1.80	0.048	−1.14	0.773	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
1.73	0.030	1.57	0.164	LOC686240	Similar to NMDA receptor regulated 1-like
1.72	0.015	1.05	0.833	MRPL24	Mitochondrial ribosomal protein L24
1.71	0.018	−0.95	0.888	ACSL4	Acyl-CoA synthetase long-chain family member 4
1.68	0.037	1.05	0.876	GSK3B	Glycogen synthase kinase 3 beta
1.68	0.018	−1.03	0.878	GFM1	G elongation factor, mitochondrial 1
−2.93	0.006	−1.58	0.638	THY1	Thy-1 cell surface antigen
−2.41	0.017	−2.23	0.018	ECH1	Enoyl CoA hydratase 1, peroxisomal
−2.31	0.015	−1.11	0.750	HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
−2.21	0.034	−2.84	0.010	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide
−2.06	0.047	−1.14	0.658	IRF3	Interferon regulatory factor 3
−1.99	0.006	−1.07	0.768	PTPRA	Protein tyrosine phosphatase, receptor type, A
−1.88	0.010	1.09	0.679	SLC6A6	Solute carrier family 6 (neurotransmitter transporter, taurine), member 6
−1.86	0.005	−1.13	0.214	ITGA7	Integrin, alpha 7
−1.83	0.038	−1.98	0.000	CST3	Cystatin C
−1.83	0.015	−1.54	0.055	IVD	Isovaleryl-CoA dehydrogenase

IPA, Ingenuity® pathway analysis; WKY, Wistar Kyoto; SHR, spontaneously hypertensive rat.