Table 7.
Number of altered genes with predicted transcription factor binding sites in WKY and SHR
| (A) Altered in WKY | (B) Altered in SHR | ||||
|---|---|---|---|---|---|
| Transcription factor | WKY # | SHR # | Transcription factor | WKY # | SHR # |
| GATA-1 | 24 | 0 | AML-1a | 0 | 54 |
| Zic1 | 24 | 0 | AML1 | 0 | 54 |
| PR | 23 | 0 | Pax-2 | 0 | 24 |
| NF-E2 | 22 | 0 | IRF-1 | 0 | 20 |
| AP-1 | 22 | 0 | MyoD | 0 | 19 |
| STAT3 | 22 | 0 | PPARα:RXR-α | 0 | 19 |
| NF-kappaB (p65) | 21 | 0 | NERF1a | 0 | 18 |
| Ik-1 | 20 | 0 | Myogenin | 0 | 18 |
| Zic2 | 20 | 0 | E2A | 0 | 18 |
| GR | 20 | 0 | TATA | 0 | 17 |
| PBX | 19 | 0 | E12 | 0 | 17 |
| YY1 | 18 | 0 | SMAD-4 | 0 | 17 |
| CDP | 13 | 0 | PEBP | 0 | 15 |
| SOX-9 | 13 | 0 | SF-1 | 0 | 14 |
| Crx | 13 | 0 | T3R | 0 | 14 |
| ELF-1 | 13 | 0 | ERR alpha | 0 | 13 |
| HNF4, COUP | 12 | 0 | MEIS1A:HOXA9 | 0 | 12 |
| SREBP-1 | 11 | 0 | CDP CR1 | 0 | 11 |
| OCT1 | 7 | 0 | Zic3 | 0 | 11 |
Symbol of transcription factor or regulatory-binding site followed by full name and the TFBS accession number in brackets. AML1,acute myeloid leukemia 1 (also known as runt-related transcription factor 1, Runx1) [M00751]; AML-1a, acute myeloid leukemia 1a, transcription factor encoded by AML1 [M00271]; AP-1, activator protein 1 [M00174, M00188, M00925, M00926]; CDP, CCAAT displacement protein/Cut homeobox [M00095]; CDP CR1, Cut repeat 1 of CDP [M00104]; Crx, cone-rod homeobox [M00623]; E12, E box protein E12 [M00693], E2A, E2A immunoglobulin enhancer-binding factors E12/E47 (also known as TCF3, transcription factor 3 [M00973], ELF-1, E74-Like Factor 1 (Ets Domain Transcription Factor) [M00746]; ERR alpha, estrogen-related receptor, alpha [M00511]; GATA-1, GATA-binding protein 1 [M00127]; GR, Glucocorticoid receptor (also known as nuclear receptor subfamily 3, group C, member 1, NR3c1) [M00955]; HNF4, hepatocyte nuclear factor 4, alpha [M00967]; Ik-1, IKZF1-IKAROS family zinc finger 1 [M00086]; IRF-1, interferon regulatory factor 1 [M00062]; MEIS1A:HOXA9, homeobox A9 [M00420]; MyoD, myogenic differentiation 1 [M00001, M00184]; myogenin [M00712]; NF-E2, nuclear factor, erythroid derived 2 [M00037]; NERF1a, E74-like factor 2 (ets domain transcription factor) [M00531]; NF-kappaB (p65), nuclear factor of kappa light polypeptide gene enhancer in B cells [M00052]; OCT1, organic cation transporter 1, POU class 2 homeobox 1 [M00135]; Pax-2, paired box 2 [M00486]; PBX, pre-B-cell leukemia homeobox 1 [M00998]; PEBP, phosphatidylethanolamine-binding protein 1 [M00984]; PPARα, peroxisome proliferator-activated receptor alpha [M00518]; SF-1, splicing factor 1 [M00727]; SMAD-4, SMAD family member 4 [M00733]; SOX-9, SRY (sex determining region Y)-box 9 [M00410]; SREBP-1, Sterol regulatory element-binding transcription factor 1 [M00220]; T3R, Thyroid hormone receptors [M00963]; TATA, TATA box [M00216]; YY1, YY1 transcription factor [M00059]; Zic1, Zic family member 1 [M00448]; Zic2, Zic family member 2 [M00449]; Zic3, Zic family member 3 [M00450]. WKY, Wistar Kyoto; SHR, spontaneously hypertensive rat.