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. 2013 Oct 14;110(46):18650–18655. doi: 10.1073/pnas.1308206110

Fig. 5.

Fig. 5.

ATM and BRCA1 are required for DIM radioprotection. (A) The 184A1 cells were pretreated with control-siRNA or ATM-siRNA, treated ± DIM for 24 h, irradiated, and assayed for clonogenic survival. Knockdown of ATM is shown in the inset Western blot. (B and C) ATM-competent (+/+) MRC5 (B) or ATM mutant (−/−) AT5 (C) fibroblasts were pretreated ± DIM for 24 h, irradiated, and assayed for survival. The Western blot inset in C shows ATM protein levels. (D) Brca1-competent (Brca1+/+) or deficient (Brca1−/−) MEFs were pretreated ± DIM for 24 h, irradiated, and assayed for survival.