Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct 25;110(46):18608–18613. doi: 10.1073/pnas.1317191110

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — Effects of Dicer deletion and inflammation on the miRNA profile of mouse CTLs. (A) Expression (reads per kb per million; RPKM) of individual miRNAs in control (Dicer^+/+, Upper; Dicer^+/fl, Lower) and Dicer^−/− CTLs, differentiated with 100 U/mL IL-2 for 6 days. Two biological replicates are shown. (B) Expression (RPKM) of individual miRNAs in wild-type P14 CTLs differentiated for 6 days in 100 U/mL IL-2 or 100 U/mL IL-2 plus IL-12 and CpG. miRNAs down-regulated (red) or up-regulated (blue) by inflammation (greater than twofold change in both biological replicates) are shown. (C) Log-twofold change of miRNAs between Dicer^−/− and control CTLs. Each dot represents a single miRNA; dots falling in the lower left quadrant are down-regulated in Dicer^−/− compared with controls. (D) As in C, except that miRNAs in wild-type effector CTLs from P14⁺TCRα^−/− mice obtained by culture in 100 U/mL IL-2 with and without inflammation are compared. Each dot represents a single miRNA; dots in the lower left quadrant (red) and in the upper right quadrant (blue) are down-regulated and up-regulated more than twofold by inflammation, respectively.