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. 2013 Oct 30;110(46):18698–18703. doi: 10.1073/pnas.1308596110

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Fig. 5. — Ikbkap is required for the second wave of neurogenesis in the DRG. (A) The number of H3⁺ progenitors is reduced in CKO embryos at E10.5 and E11.5. (B and C) E11.5. Pax3⁺ progenitors colonize the dorsal pole and perimeter of the murine DRG (B) and are depleted in Ikbkap CKO embryos (C). (D and E) The number of apoptotic cells is consistently higher in mutant embryos compared with controls (D), with TUNEL⁺ cells concentrated in the DRG progenitor zones (E). (F) Compared with controls, the number of p53⁺ cells is also dramatically higher in Ikbkap CKO embryos. (Scale bar: 40 μm.) *P < 0.05; ***P < 0.001.