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. 2013 Oct 28;110(46):E4335–E4344. doi: 10.1073/pnas.1315512110

Fig. 3.

Fig. 3.

Pathogenicity of anti-fibrinogen antibodies. (A) Mice were perfused on day 0 with elastase and randomly selected to receive an i.v. dose of 250 μg of the indicated mAb or isoptype control. On day 14 following elastase perfusion, the aortic diameter (AD) was reassessed and increase in AD was expressed in percentage (%). AAA is defined as an increase in AD of >100% over the preperfused diameter. Values represent mean ± SEM; each symbol represents an individual mouse. Day 14 elastic fiber degradation (B) and SMC actin content (C) were graded on a scale of 1–4 according to the keys shown on the Right and detailed in Materials and Methods. Values represent mean ± SEM, n = 5 aortas per genotype per treatment, six to nine slides per aorta. (Scale bar, 40 μm.) *P < 0.05, **P < 0.001, NS, not significant.