Fig. 2.

Results for the fraction of perfused vessels as a function of the vessel diameter and the vessel wall pore size, a determinant of vascular permeability. Two values of the hydraulic conductivity of the interstitial space were used: (A) 1 × 10⁻⁷ cm²/mmHg-s and (B) 1 × 10⁻⁶ cm²/mmHg-s. The compressed central region occupies 80% of the tumor. The colors represent the values of the fraction of perfused vessels and the dashed line depicts the region within which vessel decompression is beneficial. The fraction of the well-perfused vessels becomes optimal for uncompressed (larger diameter) and low-permeable (smaller vessel wall pore size) vessels. The fraction of perfused vessels decreases if the tumor vessels are compressed or hyperpermeable. Vessel decompression is beneficial for compressed and low-permeable vessels.