Table 2.

Studies showing stress alleviation decompresses vessels and improves perfusion

Therapeutic agent	Target	Tumor model	Effect on vessel diameter/density (refs.)	Effect on perfusion (refs.)
Diptheria toxin	Cancer cells	Soft tissue sarcoma	↑ (24)	Not reported
Taxane	Cancer cells	Soft tissue sarcoma	↑ (23)	Not reported
Saridegib	Stromal cells	Pancreatic ductal carcinoma	↑ (25, 27)	↑ (25, 27)
PEGPH20	Hyaluronan	Pancreatic ductal carcinoma	↑ (28, 29)	↑ (28, 29)
1D11	Collagen	Mammary carcinoma	↑ (30)	↑ (30)
Losartan	Stromal cells, hyaluronan, collagen	Pancreatic ductal carcinoma	↑ (26)	↑ (26)

Diphtheria toxin is preferentially toxic to human cancer cells and thus preferentially kills cancer cells in a human tumor xenograft model. Taxane is a chemotherapeutic agent. Saridegib is an inhibitor of the Hedgehog cellular signaling pathway. PEGPH20 is a PEGylated human recombinant hyaluronidase. 1D11 is a TGF-β neutralizing antibody. Losartan is an angiotensin receptor blocker.