Fig. 5.

Local protein interaction network for the human orthologs of protein coding genes identified in the SB mutagenesis screen. Local protein interactome hubs for MAP3K1, CREBBP, and NFIA are circled as A, B, and C, respectively. Nodes colored in red represent proteins encoded by CIS-derived candidate genes that overlap with the Wu et al. (15) dataset, whereas yellow nodes represent the proteins that interact with these CIS-derived candidates. Nodes with a diamond shape represent proteins with an annotated role in DNA-dependent transcription.