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Role of DNA mismatch repair in nrdA specificity-site mutators (mutant frequencies for rifampicin-resistant mutants). (A) Comparison of MMR+ and MMR− (mutS) derivatives of indicated nrdA mutants. Numbers above the bars indicate the fold increase due to the mutS defect, reflecting the efficiency of MMR. (B) Effect of MutL overproduction due to presence of plasmid pMQ350 (mutL+). Numbers above the bars indicate the fold reduction in MMR by the plasmid.
