(A) Structural alignment of WT A1 (1auq, black), Type 2B I1309V A1 (1ijk, dark grey), and Type 2B R1306Q A1 extracted from the cocrystal complex with GP1bα (1m10, light grey). (B) Root mean squared deviation of all backbone atoms. Top: R1306Q—WT. Bottom: I1309V—WT. Diffraction resolutions are for WT, for R1306Q, and for I1309V. Horizontal line indicates residues within the disulfide bond.