Figure 2.

Stereo diagrams showing 2Fo-Fc electron density contoured at 1σ for the four compounds soaked into Ask1/compound 1 co-crystals. A: compound 2, B: compound 3, C: compound 4, D: compound 5. To calculate the electron density maps the structure was refined using the programme Buster²¹ in the absence of the ligand. Fc and phases were calculated for the structure with the ligand not included. The figure was generated with PyMol (Delano Scientific). For compound 3 the electron density (2b) allows the azaindole group to be placed unambiguously.