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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2013 Sep 9;26(6):10.1111/pcmr.12158. doi: 10.1111/pcmr.12158

Figure 3. The Gadd34-PP1α complex mediates eIF2α dephosphorylation upon ER stress in Oca2-null melanocytes.

Figure 3

(a) Immunoblot analysis of Oca2-null melanocytes transfected with either Gadd34 or control siRNA for 48 h, and treated with 75 nM thapsigargin for 3 h. (b) Oca2-null melanocytes were pre-treated with 50 μM guanabenz for 30 min, then dosed with 75 nM thapsigargin and an additional dose of guanabenz for 2.5 h. Phospho-eIF2α levels were determined by immunoblot analysis.