FIGURE 5.

Tim-3 blockade exacerbates adhesion formation in the peritoneal cavity of WT mice. C57BL/6J mice were treated with Tim-3Ig or a control human IgG1, 250 μg s.c. at −24, 0, and 24 h relative to cecal abrasion surgery. Six days after surgery, the mice were euthanized and scored for adhesions. *, p < 0.0001; Mann-Whitney U test. The bars indicate median adhesion scores. For these experiments, 10 mice received Tim-3 Ig and 12 mice received IgG control Ab.