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Effects of the aqueous extract of CS seeds, DEX and ST on pain responses in Hot plate model. The administration of the CS extract (125, 250, 500 and 1000 mg/Kg IP) or DEX (0.5, 1 and 2 mg/Kg IP) or ST 30 min before the Hot plate test increased the reaction time (p < 0.01). Besides, the pretreatment of NAL reversed this effect. Data are expressed as the mean ± SEM. *p < 0.01, **p < 0.001 as compared with Cont or VEH groups,# p < 0.01 as compared with CS 1000.
