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Formulation of the nasal inserts of metoclopramide hydrochloride.
| Formulation Code | Xanthan: Guar Ratio | Xanthan gum (mg) | Guar gum (mg) |
|---|---|---|---|
| M1 | 0:1 | ---- | 20 |
| M2 | 1:0 | 20 | ---- |
| M3 | 1:20 | 0.95 | 19.04 |
| M4 | 1:10 | 1.81 | 18.17 |
| M5 | 1:5 | 3.33 | 16.66 |
| M6 | 1:3 | 5 | 15 |
| M7 | 1:2 | 6.66 | 13.33 |
| M8 | 2:1 | 13.33 | 6.66 |
| M9 | 3:1 | 15 | 5 |
| M10 | 1:1 | 10 | 10 |
Metoclopramide hydrochloride (10 mg) and mannitol (10 mg) were incorporated in each formulation; the total weight of polymer was maintained at 2% w/w of gel solution.
