Table 2.
Week 0 | Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 11 | ||
---|---|---|---|---|---|---|---|---|---|
XQ | Real Acup | 0 (0) | 8.3 (2.6) | 14 (2.5) | 20.9 (3.3) | 20.5 (2.8) | 23 (3.5) | 25.3 (4.1) | 17.1 (3.3) |
Sham Acup | 1.9 (1.3) | 12.4 (1.8) | 25 (2.8) | 33.2 (3.6) | 37.8 (3.5) | 38.9 (3.6) | 44.6 (3.8) | 38.9 (3.3) | |
P-value | 0.17 | 0.56 | 0.08 | 0.006 | 0.0004 | <0.0001 | <0.0001 | <0.0001 | |
MDASI SYM | Real Acup | 0.4 (0.2) | 5.9 (1.2) | 8.1 (1.4) | 11.8 (1.7) | 12 (2.3) | 15.1 (2.3) | 15.2 (2.2) | 4.8 (1.3) |
Sham Acup | 2.4 (0.8) | 6.8 (1.5) | 10.9 (1.9) | 14.6 (2.1) | 15.4 (1.7) | 17.9 (2.5) | 21.1 (3.8) | 4.7 (1.4) | |
P-value | 0.04 | 0.67 | 0.91 | 0.54 | 0.35 | 0.28 | 0.28 | 0.57 | |
MDASI INT | Real Acup | 0.3 (0.2) | 2.2 (0.8) | 3.9 (0.9) | 6.5 (1.0) | 7 (0.9) | 8.6 (1.7) | 10.3 (1.7) | 3.5 (1.1) |
Sham Acup | 0.7 (0.3) | 4.6 (0.7) | 7.2 (1.2) | 9.1 (1.3) | 9.7 (1.5) | 12.6 (1.4) | 14 (2.0) | 5.8 (1.3) | |
P-value | 0.24 | 0.2 | 0.008 | 0.004 | 0.003 | 0.03 | 0.03 | 0.22 | |
MDASI HN | Real Acup | 0.8 (0.4) | 4.4 (1.1) | 9 (1.7) | 17 (2.1) | 17.9 (1.7) | 21.9 (2.4) | 25.9 (1.9) | 11.1 (1.1) |
Sham Acup | 1.2 (0.5) | 5.8 (0.8) | 12.7 (1.5) | 20.2 (1.9) | 25.6 (1.5) | 28.5 (2.0) | 36.8 (2.8) | 14.9 (1.4) | |
P-value | 0.56 | 0.91 | 0.13 | 0.004 | 0.0005 | <0.0001 | <0.0001 | 0.11 | |
UWSFR | Real Acup | 2.3 (0.5) | 1.3 (0.2) | 1.3 (0.3) | 1.3 (0.2) | 1.2 (0.2) | 0.6 (0.1) | ||
Sham Acup | 2.0 (0.3) | 1.2 (0.2) | 1.3 (0.2) | 1.0 (0.2) | 0.8 (0.1) | 0.4 (0.1) | |||
P-value | 0.71 | 0.61 | 0.73 | 0.72 | 0.84 | 0.88 | |||
SSFR | Real Acup | 4.2 (0.9) | 2.9 (0.7) | 2.4 (0.6) | 2.1 (0.6) | 1.9 (0.3) | 1.4 (0.2) | ||
Sham Acup | 3.4 (0.4) | 2.4 (0.5) | 2.4 (0.4) | 1.4 (0.2) | 1.4 (0.2) | 1.3 (0.3) | |||
P-value | 0.44 | 0.65 | 0.58 | 0.56 | 0.52 | 0.54 |
P values at each time point are based on the LSMEAN group comparison analyses from the Mixed Model procedure.
Acup = Acupuncture; XQ = Xerostomia Questionnaire; MDASI = MD Anderson Symptom Inventory; SYM = Symptom subscale; INT = Interference subscale; HN=Head and Neck subscale; UWSFR = unstimulated whole salivary flow rates; SSFR = stimulated salivary flow rates