Table 2.
Allele frequencies in controls by ethnicity
| Variant | Allele | African American | Caucasian | Hispanic | Asian | LR χ2 a | P value |
|---|---|---|---|---|---|---|---|
|
| |||||||
| N (frequency) | N (frequency) | N (frequency) | N (frequency) | ||||
| rs6011280 | C | 32 (0.41) | 45 (0.36) | 18 (0.39) | 8 (0.20) | 5.91 | 0.116 |
| A | 46 (0.59) [0.62]c |
79 (0.64) [0.72] |
28 (0.61) | 32 (0.80) [0.73] |
|||
| rs6090041 | G | 37 (0.47) | 28 (0.23) | 14 (0.30) | 6 (0.15) | 18.33 | 0.0004b |
| A | 41 (0.53) [0.49] |
94 (0.77) [0.59] |
32 (0.70) | 34 (0.85) [0.69] |
|||
| rs6090043 | C | 34 (0.44) | 51 (0.42) | 21 (0.46) | 15 (0.38) | 0.66 | 0.883 |
| T | 44 (0.56) [0.52] |
71 (0.58) [0.51] |
25 (0.54) | 25 (0.62) [0.63] |
|||
| rs2229205 | T | 6 (0.07) | 28 (0.19) | 8 (0.14) | 4 (0.10) | 7.75 | 0.051 |
| C | 80 (0.93) [0.87] |
118 (0.81) [0.86] |
50 (0.86) | 36 (0.90) [0.87] |
|||
| rs2295448 | T | 12 (0.14) | 18 (0.12) | 4 (0.07) | 4 (0.10) | 2.17 | 0.537 |
| C | 72 (0.86) | 128 (0.88) | 54 (0.93) | 36 (0.90) | |||
a
Probabilities calculated with likelihood ratio (LR) χ2 test with 3 degrees of freedom (df) for the differences in allele frequencies of the control groups among the African American, Asian, Caucasian, and Hispanic groups.
b
Point-wise significant P values are in bold.
c
Allele frequency from HapMap of the allele in line 2 is provided in brackets under each variant except rs2295448, for which there is no data in HapMap. The allele frequency for the African Americans are from the HapMap-YRI (Sub-Saharan African), for the Caucasian from the HapMap-CEU (European), and for the Asian from the HapMap-HCB (Asian) (dbSNP, Build 130).