Table 5.
Genes from the hypothesis-based gene lists of the Kreek (Table S1) and Gershon (Table S2) containing the ten variants ranked by significance
| Symbol | Gene | Gene locationa |
Variant | Variant location |
Distance from closet annotated gene (nucleotides) |
Allele associated with heroin addictionb |
T-statistic | P | Rankc |
|---|---|---|---|---|---|---|---|---|---|
| A. Caucasian | |||||||||
| GRM8 | glutamate receptor, metabotropic 8 | 7q31.33 | rs6467108 | intron | C | 5.56 | 0.0003 | 1 | |
| NCAM1 | neural cell adhesion molecule 1 | 11q23.1 | rs1245124 | intron | T | 5.10 | 0.0003 | 2 | |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
9q22.33 | rs2779577 | intron | C | 4.99 | 0.0003 | 3 | |
| GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 |
5q34 | rs10515827 | intron | T | 4.89 | 0.0003 | 4 | |
| KCNA1 | potassium voltage-gated channel, shaker-related subfamily, member 1 |
12p13.32 | rs10492065 | down | 21,439 | T | 6.08 | 0.0007 | 5 |
| GRIK4 | glutamate receptor, ionotropic, kainate 4 |
11q23.3 | rs10502240 | intron | A | 5.88 | 0.0007 | 6 | |
| KCND2 | potassium voltage-gated channel, Shal-related subfamily, member 2 |
7q31.31 | rs917901 | intron | G | 5.50 | 0.0007 | 7 | |
| GABRG3 | gamma-aminobutyric acid (GABA) A receptor, gamma 3 |
15q12 | rs1378101 | intron | A | 4.97 | 0.0007 | 8 | |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4 |
5q33.1 | rs9325102 | intron | C | 5.02 | 0.0010 | 9 | |
| OLIG2 | oligodendrocyte lineage transcription factor 2 |
21q22.11 | rs2180 | up | 53,874 | G | 5.0 | 0.0010 | 10 |
| B. African American | |||||||||
| PDE4B | phosphodiesterase 4B, cAMP-specific | 1p31.3 | rs10493398 | intron | G | 7.20 | 0.0079 | 1 | |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
16p13.2 | rs10518152 | intron | A | 5.73 | 0.0079 | 2 | |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | rs524874 | intron | A | 5.51 | 0.0079 | 3 | |
| GLRA3 | glycine receptor, alpha 3 | 4q34.1 | rs1491402 | intron | C | 4.58 | 0.0079 | 4 | |
| SERPINA6 | serpin peptidase inhibitor, clade A | 14q32.13 | rs8023023 | intron | C | 4.47 | 0.0079 | 5 | |
| PLA2G4F | phospholipase A2, group IVD (cytosolic) |
15q15.1 | rs3825786 | down | 2,257 | T | 4.17 | 0.0079 | 6 |
| GRIA4 | glutamate receptor, ionotropic, AMPA 4 |
11q22.3 | rs502300 | intron | T | 4.05 | 0.0079 | 7 | |
| DTNBP1 | dystrobrevin binding protein 1 | 6p22.3 | rs9296978 | intron | G | 3.84 | 0.0079 | 8 | |
| rs2743868 | intron | C | 3.80 | 0.0079 | 9 | ||||
| TPH2 | tryptophan hydroxylase 2 | 12q21.1 | rs10506645 | intron | A | 3.80 | 0.0079 | 10 | |
a
Gene location from UCSC Genome Browser, March 2006 assembly (NCBI Build 36.1).
b
Allele more frequent in cases than controls
c
Rank is based on ascending P value. If the point-wise non-parametric Ps for several variants are the same, the variant with the larger T-statistic is ranked higher.