Table 2. The highest comparison scores between TOG superfamily members.
Protein representatives of families used in these comparisons are found in tables S1–S9. Representative alignments for highlighted squares are usually provided in figures S1–S7 and S9–S10, but in some cases better scores are reported here than in the figures, based on other alignments. Values above 12.0 S.D., which are considered sufficient to establish homology and interconnect families, are shaded. These values are sufficient to establish homology based on the criteria discussed in the methods section1,2.
| 9.A.14 GPCR |
2.A.102 TSUP |
2.A.82 OST |
3.E.1 MR |
9.A.58 Sweet |
2.A.52 NiCoT |
2.A.58 PNaS |
4.B.1 PnuC |
|
|---|---|---|---|---|---|---|---|---|
| 9.A.14 GPCR |
||||||||
| 2.A.102 TSUP |
11.4 S.D. (2 TMSs) |
|||||||
| 2.A.82 OST |
10.8 S.D. (2 TMSs) |
12.1 S.D. (2 TMSs) |
||||||
| 3.E.1 MR |
13.1 S.D. (2 TMSs) |
11.0 S.D. (2 TMSs) |
12.4 S.D. (3 TMSs) |
|||||
| 9.A.58 Sweet |
12.3 S.D. (2 TMSs) |
10.1 S.D. (3 TMSs) |
12.3 S.D. (2 TMSs) |
11.2 S.D. (2 TMSs) |
||||
| 2.A.52 NiCoT |
10.4 S.D. (2 TMSs) |
12.8 S.D. (3 TMSs) |
11.9 S.D. (2 TMSs) |
10.7 S.D. (2 TMSs) |
11.8 S.D. (3 TMSs) |
|||
| 2.A.58 PNaS |
11.2 S.D. (2 TMSs) |
10.6 S.D. (2 TMSs) |
11.5 S.D. (4 TMSs) |
13.1 S.D. (3 TMSs) |
11.6 S.D. (2 TMSs) |
12.2 S.D. (3 TMSs) |
||
| 4.B.1 PnuC |
10.2 S.D. (3 TMSs) |
13.9 S.D. (2 TMSs) |
11.4 S.D. (2 TMSs) |
10.9 S.D. (2 TMSs) |
13.1 S.D. (3 TMSs) |
11.2 S.D. (2 TMSs) |
9.8 S.D. (2 TMSs) |
|
| 2.A.43 LCT |
9.4 S.D. (3 TMSs) |
11.3 S.D. (2 TMSs) |
11.1 S.D. (2 TMSs) |
11.0 S.D. (2 TMSs) |
13.6 S.D. (2 TMSs) |
11.5 S.D. (2 TMSs) |
12.8 S.D. (3 TMSs) |
11.3 S.D. (3 TMSs) |
Average comparison score and average number of TMSs in all TOG superfamily alignments: 2.3 TMSs; 11.5 S.D.
Average comparison score and average number of TMSs in alignments used to establish homology and interconnect all families within the TOG superfamily: 2.5 TMSs; 12.8