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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2013 Sep 27;230(2):10.1007/s00213-013-3276-5. doi: 10.1007/s00213-013-3276-5

Fig. 1. Chemical structures of three prototype endogenous neurosteroids.

Fig. 1

THDOC differs from allopregnanolone by a 21β-hydroxyl group, while androstane differs from allopregnanolone by a 17β-hydroxyl group instead of 17β-methyl-carbonyl group. Synthetic analogs of neurosteroids are prepared by additional moieties at C3-position (ganaxolone), C11-position (alphaxolone), and C2- and C11-positions (minaxolone).