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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2013 Sep 27;230(2):10.1007/s00213-013-3276-5. doi: 10.1007/s00213-013-3276-5

Fig. 7. Comparative efficacy of allopregnanolone on GABA-gated currents in wildtype (A) and δ-subunit knockout (B) mouse dentate gyrus granule cells.

Fig. 7

Concentration-dependent responses of allopregnanolone (AP) potentiation of inward chloride current in the presence of 3 μM GABA in DGGCs. Recordings were at -70 mV voltage-clamp, whole-cell patch of in acutely dissociated DGGCs. GABA was first locally applied to the bath solution for 5 seconds to establish a baseline level of gated, inward chloride current. Increasing concentrations of AP were applied for 10 seconds. After 5 seconds of application, GABA perfusion was initiated, resulting in concentration-dependent potentiation by AP. AP alone did not elicit a change in current, however, at 500 nM and 1 μM concentrations, AP application produced a slight inward current.