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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2013 Sep 27;230(2):10.1007/s00213-013-3276-5. doi: 10.1007/s00213-013-3276-5

TABLE 2.

Neurosteroid and gaboxadol pharmacology for specific GABAAreceptors.

Drug Interaction Efficacy Potency References
Allopregnanolone & αxβ1γ2 α4 > α1 > α6 > α5 > α3 >
α2		 α3 > α1 > α2 > α6 > α5 >
α4		 Belelli et al., 2002
Allopregnanolone & αxβsδ α6 > α4 α4 > α6 Brown et al., 2002;
Pillai et al., 2004
THDOC α1β2/3γ2 > α5β3γ2 α5β3γ2 ≈ α1β3γ2 Caraiscos et al., 2004
Gaboxadol α6β3γ2 > α1β2/3γ2 >
α4β3γ2 > α4β3δ >
α6β3δ		 α6β3δ > α4β3δ >
α6β3γ2 > α4β3γ2 >
α1β2/3γ2		 Saarelainen et al., 2008;
Mortensen et al., 2010;
Meera et al., 2011