Table 2.
Multivariable linear regression of DNA methylation (log DPM/μg) by prenatal, early life, adolescent and adult variables.
| Linear Multivariate Model 1 |
Linear Multivariate Model 2 |
Linear Multivariate Model 2 |
|
|---|---|---|---|
|
| |||
| Beta (95% CI) | Beta (95% CI) | Standardized Beta | |
|
| |||
| Prenatal | |||
|
| |||
| Prenatal Smoke Exposure | −0.34 (−0.65, −0.02) | −0.38 (−0.70, −0.07) | −0.32 |
|
| |||
| Race | |||
| Black : White | 0.20 (−0.14, 0.54) | 0.17 (−0.17, 0.51) | 0.15 |
| Hispanic : White | −0.14 (−0.45, 0.17) | −0.15 (−0.45, 0.16) | −0.12 |
|
| |||
| Family Socioeconomic Status | −0.01 (−0.01, 0.001) | −0.01 (−0.01, 0.002) | −0.18 |
|
| |||
| Early Life | |||
|
| |||
| Birth Weight (kg) | 0.33 (−0.06, 0.72) | 0.28 (−0.11, 0.67) | 0.26 |
|
| |||
| Birth Length (cm) | −0.11 (−0.19, −0.02) | −0.11 (−0.19, −0.03) | −0.46 |
|
| |||
| Adolescent | |||
|
| |||
| Age at Menarche (years) | −0.07 (−0.13, −0.004) | −0.23 | |
|
| |||
| Childhood Passive Smoke Exposure | 0.15 (−0.19, 0.48) | 0.25 (−0.08, 0.58) | 0.19 |
|
| |||
| Adult | |||
|
| |||
| Current BMI (≥ 25 kg/m2 : <25 kg/m2) | −0.19 (−0.46, 0.07) | −0.21 (−0.48, 0.05) | −0.19 |
|
| |||
| Smoking Status | |||
| Former : Never | −0.02 (−0.30, 0.27) | −0.17 (−0.46, 0.12) | −0.14 |
| Current : Never | 0.15 (−0.20, 0.50) | 0.17 (−0.17, 0.52) | 0.12 |
|
| |||
| Parity (Nulliparous : Parous) | −0.30 (−0.57, −0.02) | −0.25 | |
|
| |||
| Age at First Birth | −0.03 (−0.06, −0.01) | −0.35 | |