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. 2013 Nov 18;8(11):e81018. doi: 10.1371/journal.pone.0081018

Figure 3. Mediation of peripheral afferents in the inhibitory effects of acupuncture at HT7 on cocaine locomotion.

Figure 3

A: Effect of pretreatment with the local anesthetic bupivacaine on the effects of acupuncture at HT7. Inhibition of cocaine locomotion following mechanical stimulation to HT7 was prevented by infiltration around acupoints with bupivacaine. (*P<0.05 vs. Con group (cocaine only); #P<0.05 vs. Saline+HT7 group; Con, n=7; Saline+HT7, n=12; Bupivacaine+HT7, n=12). B: Effect of needling to HT7 at different depths on cocaine locomotion. The HT7 effects are produced by either superficial (1 mm) or deep (3 mm) tissue stimulation (*P<0.05 vs. control; Con, n=11; HT7-1mm, n=12; HT7-3mm, n=12). Data are presented as mean ± SEM and analyzed by two-way repeated ANOVA with Holm-Sidak post hoc comparison.