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. 2013 Nov 18;8(11):e81018. doi: 10.1371/journal.pone.0081018

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© 2013 Kim et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A-C: Somatic afferent responses of Pacinian corpuscle fibers (n=9) during MAI stimulation of HT7. A: An example of event traces and frequency histogram of Pacinian corpuscle fiber during high frequencies stimuli with tuning fork (256 Hz). B: Frequency histogram of response to HT7 MAI stimulation (10 sec). Frequencies of discharge activity dramatically increased during MAI stimulation of HT7, compared to values before MAI stimulation (C).

D-F: Somatic afferent responses of Meissner corpuscle fibers (n=8) during MAI stimulation of HT7. D: An example of event traces and frequency histogram of Meissner corpuscle fiber during the sustained pressure on HT7 for about 7 sec with von Frey 8 gram force. E: Frequency histogram of response to HT7 MAI stimulation (10 sec). Frequencies of discharge activity significantly increased during MAI stimulation of HT7, compared to values before MAI stimulation (F). Data are presented as mean ± SEM and analyzed by paired Student’s t-test. * indicates significance at p≤ 0.05.