Table 1.
Characteristic | AD-exposed n=8,833 |
(%) | AD-not exposed n=646,782 |
(%) | P-valued |
---|---|---|---|---|---|
Maternal age at conception | <0.001 | ||||
<21 years | 373 | 4.2 | 25,869 | 4.0 | |
21–25 years | 1,564 | 17.7 | 125,783 | 19.4 | |
26–30 years | 3,044 | 34.5 | 259,853 | 40.2 | |
31–35 years | 2,669 | 30.2 | 178,433 | 27.6 | |
≥36 years | 1,183 | 13.4 | 56,844 | 8.8 | |
Paternal age at conception | <0.001 | ||||
<25 years | 1,071 | 12.1 | 75,696 | 11.7 | |
26–30 years | 2,388 | 27.0 | 211,695 | 32.7 | |
31–35 years | 2,587 | 29.3 | 209,555 | 32.4 | |
≥36 years | 2,371 | 26.8 | 136,072 | 21.0 | |
Data missing | 416 | 4.7 | 13,764 | 2.1 | |
Parental psychiatric historya | <0.001 | ||||
Yes | 1,897 | 21.5 | 17,853 | 2.8 | |
No | 6,523 | 73.8 | 615,251 | 95.1 | |
Data missing | 413 | 4.7 | 13,678 | 2.1 | |
Gestational age at birth | <0.001 | ||||
<28 weeks | 17 | 0.2 | 1,215 | 0.2 | |
28–31 weeks | 99 | 1.1 | 4,526 | 0.7 | |
32–36 weeks | 723 | 8.2 | 35,870 | 5.5 | |
≥37 weeks | 7,994 | 90.5 | 605,171 | 93.6 | |
Birth weight | <0.001 | ||||
<2,500 g | 631 | 7.1 | 31,640 | 4.9 | |
2,500–2,999 g | 1,291 | 14.6 | 71,513 | 11.1 | |
3,000–3,499 g | 2,903 | 32.9 | 196,827 | 30.4 | |
≥3,500 g | 3,973 | 45.0 | 343,054 | 53.0 | |
Data missing | 35 | 0.4 | 3,748 | 0.6 | |
Sex | 0.41 | ||||
Boy | 4,587 | 51.9 | 331,523 | 51.3 | |
Girl | 4,246 | 48.1 | 315,244 | 48.7 | |
Data missing | 0 | 0.0 | 15 | 0.0 | |
Congenital malformationb | <0.001 | ||||
Yes | 459 | 5.2 | 25,160 | 3.9 | |
No | 8,374 | 94.8 | 621,622 | 96.1 | |
Parity | 0.70 | ||||
0 | 3,780 | 42.8 | 279,513 | 43.2 | |
>1 | 5,053 | 57.2 | 367,263 | 56.8 | |
Data missing | 0 | 0.0 | 6 | 0.0 | |
Affective disorder (mother)c | <0.001 | ||||
Yes | 1,756 | 19.9 | 4,324 | 0.7 | |
No | 7,077 | 80.1 | 642,458 | 99.3 | |
Affective disorder (father)c | <0.001 | ||||
Yes | 159 | 1.8 | 3,195 | 0.5 | |
No | 8,261 | 93.5 | 629,909 | 97.4 | |
Data missing | 413 | 4.7 | 13,678 | 2.1 | |
Autism spectrum disorder | |||||
Yes | 104 | 1.2 | 5,333 | 0.8 | |
No | 8,729 | 98.8 | 641,449 | 99.2 | |
Childhood autism | |||||
Yes | 37 | 0.4 | 2,030 | 0.3 | |
No | 8,796 | 99.6 | 644,752 | 99.7 |
Notes:
One or both parents diagnosed with a psychiatric disorder before birth of the child (except maternal affective disorder) (ICD-8: 290–315 and ICD-10: All F-codes)
child diagnosed with congenital malformations (ICD-10: Q0–99 codes, except for Q53 and Q65; see text)
parent diagnosed with an affective disorder before birth of the child (ICD-8: 296.09, 296.19, 296.29, 296.39, 296.99, 298.09, 298.19, 300.49, 301.19 and ICD-10: F30–F34 and F38–F39)
test for no association between characteristic and exposure group.
Abbreviations: AD, antidepressants; n, number.