Table 4.
AD exposure | Number | Person-years at risk | Autism spectrum disorder n (%) | Crude HR (95% CI) | Adjusted HRa (95% CI) |
---|---|---|---|---|---|
Autism spectrum disorder | |||||
Exposed to AD | 11,388 | 88,921 | 100 (0.9) | 1.3 (1.04–1.5) | 1.1 (0.9–1.3) |
Exposed to SSRI | 7,536 | 59,335 | 76 (1.0) | 1.4 (1.1–1.8) | 1.3 (1.002–1.6) |
Exposed to SNRI | 1,065 | 7,718 | 9 (0.8) | 1.3 (0.7–2.6) | 1.1 (0.6–2.1) |
Exposed to TCA | 1,397 | 11,839 | 8 (0.6) | 0.7 (0.4–1.5) | 0.6 (0.3–1.3) |
Not exposed to AD | 630,136 | 5,587,702 | 5,154 (0.8) | 1.0 (ref) | 1.0 (ref) |
| |||||
AD exposure | Number | Person-years at risk | Childhood autism number (%) | Crude HR (95% CI) | Adjusted HRa(95% CI) |
| |||||
Childhood autism | |||||
Exposed to AD | 11,388 | 89,108 | 40 (0.4) | 1.2 (0.9–1.7) | 1.0 (0.7–1.4) |
Exposed to SSRI | 7,536 | 59,485 | 28 (0.4) | 1.3 (0.9–1.9) | 1.1 (0.7–1.6) |
Exposed to SNRI | 1,065 | 7,733 | 4 (0.4) | NA | NA |
Exposed to TCA | 1,397 | 11,845 | 5 (0.4) | 1.2 (0.5–2.8) | 1.0 (0.4–2.4) |
Not exposed to AD | 630,136 | 5,597,647 | 1,959 (0.3) | 1.0 (ref) | 1.0 (ref) |
Notes:
Hazard ratios were adjusted for maternal age at conception, paternal age at conception, parental psychiatric history (except paternal affective disorder), gestational age, birth weight, sex, and parity.
Abbreviations: AD, antidepressant drugs; HR, hazard ratio; n, number; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin–norepinephrine reuptake inhibitors; TCA, tricyclic antidepressants; NA, not applicable; ref, reference; CI, confidence interval.